AKT Kinase Inhibitor

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Akt 激酶抑制剂。

An Akt kinase inhibitor.

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied.Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.

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Cytoskeleton/Cell Adhesion Molecules

Akt

Akt

Cancer

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842148-40-7

357.3672

C16H19N7O3

>98% (HPLC)

10 mM in DMSO

CCN1C2=C(C(=NC=C2OCCCN)C#CCO)N=C1C3=NON=C3N

2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-

(-20℃)

With Ice Pack

≥ 2 years